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Both the back-to-back and face-to-face interfaces contain residues that have now been shown to be functionally significant by mutational studies at least in the species tested, so that both arrangements may be required for the complete Ire1 mechanistic cycle.
Finally, face to face.
Face to face.
"She came face to face with him.
They met face to face again last May.
"You're brought face to face with yourself".
Congregations meet regularly face to face.
Sometimes the fighting was face to face".
"It was face to face," Holley said.
They cannot fight face to face.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com