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However, such studies continue to face technically challenges in determining the abundance, state of modification, and localization of proteins, due to several factors, including the solubility, abundance, digestion, and enrichment of membrane proteins and N-glycosylated peptides [ 20, 21].
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Statoil also faced technical challenges.
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They face some challenges.
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I did face some challenges".
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They face formidable challenges.
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