The crew faces polar bears (two dogs are taken along to warn of approaching bears), a storm that lasts a month and the general fickleness of the ice, which buckles and swells frighteningly.
Stronger susceptance modulation is exhibited in AlGaN/GaN ASVs made from Ga-face polar material compared to N-face polar material.
The tetramer is stabilised by at least three mechanisms: first, the knob-into-holes and van der Waals packing of hydrophobic residues; second, the packing of internally facing polar residues; third, a cross-chain salt bridge formed between R208 and E210.
It is based on the BBC series, and uses augmented-reality technology to display the Northern Lights and bring visitors face-to-face with polar bears and killer whales (opens 25 March, adult £24.50, child £18.10, under-threes free, visitsealife.com).com
The pocket is dissymmetric with one hydrophobic side facing a polar region (see above).
B38 forms an unusual α-helix with a broad hydrophobic face and polar serine and threonine residues on the opposite face.
By introducing D-amino acids to replace the original L-amino acids on the non-polar face or the polar face of the helix, the hemolytic activity of peptide analogs have been significantly reduced.
In this study, helicity of peptide P was systematically modulated by introducing D-amino acids to replace the original L-amino acids on the non-polar face or the polar face of the helix.
Compared to the peptide P (MHC 5.2 μmol/L), the peptide hemolytic activity significantly decreased to no detectable hemolysis at the concentration of 325.2 μmol/L by substituting D-amino acid both on the non-polar face and the polar face of the parent peptide.
Two groups of D- and L-diastereomeric peptides were designed and the helicity was systematically modulated by introducing D-amino acids to replace the original L-amino acids on the non-polar face or the polar face of the α-helical antimicrobial peptides.
The resulting compact conformation, which we believe approximates the closed resting state of MscS, matches the hydrophobic thickness of the lipid bilayer with arginines 46, 54, and 74 facing the polar lipid headgroups.
