The U.S. Environmental Protection Agency is facing large challenges in managing environmental chemicals with increasingly complex requirements for assessing risk that push the limits of our current approaches.
Nobody has ever tried this on such a large scale, and critics worry these new investors could face big challenges managing large portfolios of dispersed rental houses.
Although the Internet facilitates information gathering and processing, investors still face great challenges given the large number of projects available.
Franklin D. Gilliam Jr., dean of UCLA's Luskin School of Public Affairs, said Garcetti's emphasis on internal city operations is "small ball" at a time when Los Angeles faces large-scale challenges — substandard schools, high unemployment and an affordable housing shortage.
Hearsay Social, a startup backed by New Enterprise Associates and Sequoia Capital, has tried to solve many of the challenges facing large brands that need to manage the social media presence of local branches or franchises.
We also face a large challenge in rebuilding an efficient, competitive private mortgage market, an area in which commercial bank participation is needed.
Mr. McCain still faces a large challenge from his right in the fall, as many conservatives suspect he isn't really one of them.
Nokia faces a large challenge in terms of stealing market share from competitors, particularly as rival handset makers Samsung, HTC and Huawei prepare to roll out their own smartphones running the same Windows Phone 8 software.
During the first season, contestants faced large-scale real-life challenges that took them beyond the game.
We describe here the rationale and methodology behind one phenotyping pipeline, EMPReSSslim, that was designed as part of the work of the EUMORPHIA and EUMODIC consortia, and which exemplifies some of the challenges facing large-scale phenotyping.
