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Radioactivity concentrations were higher in heart, lungs, stomach, intestines, and spleen for 64Cu- than 111In-DOTA-trastuzumab Fab (Table 1).
Tumor uptake was not significantly different for 64Cu- and 111In-DOTA-trastuzumab Fab, but blood radioactivity was threefold lower for 111In-DOTA-trastuzumab Fab (Table 1).
In addition to the higher levels of blood radioactivity, we found that the liver and spleen uptake for 64Cu-DOTA-trastuzumab Fab were three- and twofold greater, respectively, than 111In-DOTA-trastuzumab Fab (Table 1).
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In addition, the mean plasma concentration of dabigatran was below the limit of detection (that is, approximately zero) after the addition of both concentrations of aDabi-Fab (Table 1).
We also determined the structure of the Fab alone (Table 3); superposition of the two Fab structures showed that the R53 Fab appears to undergo a minimal conformational change upon epitope binding (RMSD = 0.77 Å).
Coagulopathy was less frequent in the F ab')2/F ab' 2 and the F ab')2/placebo groups compared with that in the Fab/Fab group, and there was an absolute risk reduction in both F ab' 2 groups compared with that in Fab group (Table 2).
The seven angiogenesis-related factors (VEGF-A, VEGF/PlGF, VEGF-C, VEGF-D, Ang-1, Ang-2, and Tie-2) in 52 AML patients at presentation were investigated, and no significant differences were observed in the age and FAB subtypes (Table 1).
Plasma from an additional lamprey (L29) also effectively blocked each of the four Fabs tested (Table 2 and Table 2 source data 2).
Although six of the Fabs recognized SpeC by ELISA (Table 1), only Fab 9 had any significant effect on SpeC-induced stimulation of T-cells.
Nuclear NPBC was found in 18 (40·9%) of 44 MDS patients, and was related to the FAB classification of MDS (Table I, Fig 2B).
Although most AMPs result only in a small number of tryptic peptides (Additional file 3), due to their small sizes, the sum of all detectable peptides resulted in more than 50% sequence coverage (except FAB, with only 34%) (Table 2).
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