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Some micro-RNAs show age-related differential regulation, higher in the sclera of rapidly growing fetal eyes, consistent with a role in ocular growth regulation.
In crosses between PPCD1 and DBA/2J mice (N5 through N8, n = 204), 52% of the offspring exhibited big eyes, consistent with autosomal dominant inheritance at a single locus, designated Ppcd1, and complete penetrance in the DBA/2J background.
In addition, all subjects had optic disc appearance in both eyes consistent with a clinical diagnosis of POAG.
We had previously reported favourable results after collagen crosslinking in adult Keratoconic eyes consistent with other published studies [ 8– 13].
Prolonged MD caused mismatch of the preferred orientation of two eyes, consistent with requirement of binocular visual experience during the critical period to develop orientation matching (Wang et al., 2010).
In cases where a shallow anterior chamber and iris bombé were present (2 subjects; 2 eyes), consistent with angle-closure glaucoma, patients were managed with a peripheral iridectomy (PI) and anterior vitrectomy; with one subject requiring further subsequent medical treatment (Table 3).
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Mf1, the murine homologue of FKHL7, is expressed in the developing brain, skeletal system, and eye, consistent with FKHL7 having a role in ocular development.
Of particular interest to this study was the conserved expression of CPA6 posterior to the eye, consistent with a role for CPA6 in the etiology of Duane syndrome.
The approach was validated with bovine serum albumin (BSA) colorimetric detection, and colorimetric results observed by naked eyes were consistent with that from apparatus.
Interestingly, the LC did not show increased overall activity to negative music with eyes closed, consistent with evidence that arousal modulation may increase effective connectivity between the LC and attention-related cortical regions without increasing activity within these regions [20], [35].
The results of this multimodal imaging approach demonstrate white matter pathways connecting the frontal eye fields and supplementary eye fields, consistent with the known connectivity of these regions in macaque monkeys.
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