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VEPs were elicited by monocular right eye stimulation.
Sixteen interictal migraine without aura patients (MO, ICHD-II code 1.1) underwent VEPs (right eye stimulation, 600 sweeps, 3.1Hz reversal rate, 15 min of arc check) and median nerve SSEPs (right stimulation, 500 sweeps, 4.4 repetition rate, 1.2 motor threshold) recordings, before and during ketogenesis, confirmed by urinary sticks.
This was associated with deficits in both the normal depression of V1 neuronal responses to deprived-eye stimulation, and potentiation of responses to non-deprived eye stimulation, which accompany ocular dominance plasticity.
Notably, this refinement was never accompanied by an expansion in the area of cortex responding to ipsilateral eye stimulation.
This indicates that the differences in the fMRI response we measured between left and right eye stimulation do not relate to eye dominance.
Thus it is unlikely that additional neurons were recruited to expand the circuitry into areas of cortex that previously did not respond to ipsilateral eye stimulation.
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The increased synaptic drive to the cortex then increased the overall response to ipsilateral eye visual stimulation, as detected in our experiments.
Unlike retinal ganglion cells, MT+ neurons do not show any preference for the eye of stimulation, so should the effect be cortical in origin we would expect the TwAE to transfer between the eyes.
This result suggests that both IL-17A and IL-17F may be involved in posterior segment inflammation of the eye through stimulation of inflammatory cytokine production by the resident cell population.
We found the slope of these curves was indeed significantly steeper under binocular versus dominant-eye-only stimulation.
During resting periods, volunteers were instructed to close their eyes; during stimulation phases, they had to look at the screen.
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