Exact(1)
The limited ∼250 µm spread of LFP is consistent with studies demonstrating robust LFP stimulus selectivity for retinotopy, eye input, orientation, direction, and even spatial phase (Liu and Newsome 2006; Berens et al. 2008; Katzner et al. 2009; Xing et al. 2009; Lashgari et al. 2012; Mineault et al. 2013).
Similar(59)
The stratified nature of the projections from layer IV to layer III is reminiscent of the pattern of ipsilateral and contralateral eye inputs to layer IV.
Therefore, there are significantly large fluctuations in the local density of the two eye inputs that could potentially create a blueprint for the establishment of ocular dominance columns.
In addition, it has also been suggested that the inhibitory system could filter the activity of the deprived eye inputs favouring plasticity processes leading to their functional disconnection [5], [39].
One possible alternative explanation of the persistency of visual c-Fos responses in PV cells of MD rats could be that this cell type can achieve c-Fos expression even in response to the weak activity elicited by visual stimulation of the deprived eye inputs.
Our data demonstrate that even in the presence of competing normal (control) eye inputs, a restricted reorganization in the LPZ in V1 is present immediately after retinal lesioning.
The absence of control eye inputs can facilitate this reorganization, as we observed in animal M4 where the optic disc of the control eye was partially superimposed on the retinal lesion.
The device will be used to stimulate the visual cortex of the monkeys to try and re-create the activity normally triggered by signals from the eyes creating the sensation of sight without the eyes' input.
Recent data have shown that some cortical cells shift their response in favour of the deprived eye, with the direction of the shift critically depending on the amount of open-eye input and the net visual drive experienced during MD [2].
Thus in these experiments LCD shutter goggles (CrytalEyes 3, StereoGraphics, San Rafael, CA, USA) were used, which allow the stimuli for both eyes to be maximally similar, thus preventing subjects from distinguishing between the two eyes' input simply by colour.
Monocular deprivation in the presence of VPA instead induced a shift toward the open-eye input as rated on a seven-point scale of neuronal responsiveness (Fig. 1b, VPA, lower panel, black bars).
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