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Mutations in Pax6 genes cause eye developmental defects in a wide range of species.
In addition, Pax is not "the gene" that coordinates all eye developmental genes.
Interestingly, many Pax6 mutations that cause eye developmental defects have mutations that disrupt the PD (van Heyningen and Williamson, 2002).
First, there are species that have members of the eye developmental cascade but do not have eyes.
For eyes to be monophyletic would require that each species inherited its eye developmental network (ancient eye scenario) rather than having independently recruited a similar developmental network (parallel recruitment scenario) or an entirely different developmental network (convergent scenario).
Nestin MO treatment resulted in brain and eye developmental defects.
Similar(39)
In the mammalian eye, the developmental sequence can be summarized as follows.
Our results predicted localization changes that underlie many different types of diseases, including those involving signal transduction, metabolism, immunodeficiencies, eye diseases, developmental disorders and cancers (see Additional file 5 and Additional file 6).
The syndrome is characterized by a mishaped nose, broad thumbs and halluces (the big toes), brachydactyly, sensorineural hearing loss, facial features such as hypertelorism (unusually wide-set eyes), and developmental delay.
Among 315 mutants identified in the Hopkins' screen (see supplemental table 3 in [5]), 157 have a similar phenotypic signature, characterized by various degrees of brain necrosis at day one, and at later stages, by a smaller head and eyes and developmental delay.
This result led us to investigate genetic variation acting in eye-specific developmental pathways.
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