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Thus, the extrusion throughput is mainly limited by the extrudate temperature rather than extrusion pressure.
By reducing screw torque, die build-up and die pressure, the new product can improve extrusion throughput by up to 110% compared to PE compounds without a processing additive, the Dow Chemical subsidiary reports.
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Deformable rare cells such as CTCs may be damaged or lost as these local perturbations create conditions where extrusion through pores occurs, especially as the throughput is increased [ 41].
For example, Wittwer et al. developed a quantitative structure-activity relationship (QSAR) model of ligand binding to the multidrug and toxin extrusion transporter 1 (MATE1, SLC47A1) by experimental high-throughput screening (HTS) for drug libraries.
LAB is characterized by excellent resolution and it has lower throughput, and it is slower than extrusion and inkjet printing modalities.
Hot-melt extrusion processing of E50LV based compositions resulted in high torque loads, low material throughput and polymer degradation.
A full factorial experimental design with 19 experiments was used to evaluate the effect of several process variables (barrel temperature: 160 200 °C, screw speed: 50 200 rpm, throughput: 0.2-0.5 kg/h) and drug load (0 20%) as formulation parameter on the hot-melt extrusion (HME) process, extrudate and tablet quality of Soluplus®-Celecoxib amorphous solid dispersions.
This should provide much better throughput.
The required throughput of each injector is greater than that of any injector built to date, and a novel twin-screw continuous extrusion system is being developed to meet the challenging design parameters.
High Throughput Screen.
(4) Maximizing patient throughput.
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