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We show that TGN1412 as well as the commercially available CD28 superagonist ANC28.1 induce a delayed but extremely sustained calcium response in human naïve and memory CD4+ T cells but not in cynomolgus T lymphocytes.
We show that, despite complete conservation of the CD28 extracellular and cytoplasmic domains, TGN1412 and a commercially available CD28SA, ANC28.1/5D10, induced a delayed but extremely sustained calcium response in human, but not in cynomolgus and rhesus monkey T cells.
Surprisingly, an extended analysis revealed that the CD28SA-mediated Ca++-signal had an extremely sustained kinetics (Fig. 2A 2F) that lasted for more than six hours without significant decrease (Fig. S2).
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Azithromycin achieves extremely high, sustained concentrations in tissues and cells.
They represent a population whose musculoskeletal system is subjected to extremely high and sustained loading [ 8].
HSF1 overexpression often leads to sustained extremely high levels of HSF1 activity, whereas cell-based assays for the heat shock response may identify compounds that cause proteotoxic damage and mimic cell stress.
Jonathan Harris, director of mortgage broker Anderson Harris, said the fact that mortgage lending had remained unchanged month-on-month was "extremely encouraging, suggesting a sustained and considered improvement in the housing market, which is more likely to lead to a measured recovery, rather than a house-price bubble".
This sounds like Autechre if they'd just sustained some extremely major head injuries, and were desperately trying to communicate by poking at the keyboard of a ZX Spectrum that had just had a cup of coffee spilt over it.
If he was, at times, understandably indignant over the state of our nation, he showed remarkable self-restraint in the face of a sustained and extremely sordid mud-sling from the other guy.
Staurosporine (ST) is a serine/threonine kinase inhibitor that induces extremely rapid, coordinated and sustained EMT in embryonic neural epithelial cells [ 31].
We found that RBX1 sustained an extremely high frequency of copy-number loss, representing a characteristic of NRF2 inhibitory complex component disruption unique to OVCA.
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