Sentence examples for extremely poor solubility from inspiring English sources

Efficient synthesis and solution processing of these materials, however, are challenging because of their extremely poor solubility.

Nickel oxide is a nickel compound with extremely poor solubility that is considered to have high biopersistence in the lung [16].

Nevertheless, the main intrinsic drawback of CNTs is their insolubility or extremely poor solubility in most of the common solvents due to their hydrophobicity, thus creating it tricky to explore and understand the chemistry of such material at the molecular level and device applications.

This is largely a consequence of their extremely poor solubility and instability in aqueous solutions, in particular at alkaline pH [ 26, 27].

Despite the fact that SN38 has efficacious activity toward tumor cells, drawbacks remain with its clinical application due to its extremely poor solubility in aqueous solution and other pharmaceutically acceptable solvents [ 6, 7].

Although T-20 is a clinically approved anti-HIV drug, it is notoriously difficult to work with due to its extremely poor solubility and its short in vivo half-life.

To overcome this extremely poor aqueous solubility, we have developed curcumin cyclodextrin (CD) complexes that remarkably enhance curcumin solubility.

JC1 dye has extremely poor water solubility, which favors the formation of J-aggregates even at 0.1 μM concentration.

Despite its extensive researches and developments, its clinical application was limited because of its side effect for normal tissue, extremely poor aqueous solubility, and it damages intestinal and hepatic metabolism [12, 13].

The clinical application of gambogic acid (GA), a natural component with promising antitumor activity, was limited due to its extremely poor aqueous solubility, rapid elimination in vivo, and wide biodistribution.

84 However, the extremely poor water solubility of UC781 leads to a great challenge for its formulation development.