Sentence examples for extremely low bioavailability from inspiring English sources

Systemic administration of bisphosphonates, e.g. sodium alendronate (Aln) is characterized by extremely low bioavailability and high toxicity.

This is because oral administration of taxoids (paclitaxel and docetaxel) presents an extremely low bioavailability, with a less than 1% extent of oral absorption [2, 3].

may all have extremely low bioavailability.

These effects are observed despite extremely low bioavailability and rapid clearance of resveratrol from the circulation (Baur and Sinclair 2006).

However, their therapeutic potential is limited by their exceedingly low bioavailability after oral administration.

Paclitaxel (PTX) is a potent anticancer drug which suffers limitations of extremely low oral bioavailability due to low solubility, rapid metabolism and efflux by P-gp transporters.

The plasma concentrations within the PR group were quite variable, resulting in an extremely low and variable bioavailability with an average of 12%.

50 INS are recommended for moderate to severe disease; concerns relating to systemic effects are unfounded when the latest molecules are used, as their systemic bioavailability is extremely low (figure 3).

Despite all biologic properties, curcumin is extremely unstable in vivo with a very low bioavailability (Anand et al. 2007).

However, the extremely low water solubility of elemental sulfur limits its bioavailability and results in a low sulfur-reduction rate.

Indeed, many of the newly discovered drug candidates suffer from low to extremely low water solubility and hence are prone to limited bioavailability [1, 2, 3].