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Likewise, in the final step, Tbr2 is extremely downregulated to undetectable levels as Tbr1 signals the transition into a postmitotic projection neuron.
However, mature muscle components were extremely downregulated in congenital muscular dystrophies [34].
In our study we found that leptin-deficient ob/ob mice have very high levels (∼5-fold) of Scd1 gene expression as compared to B6 control mice and after leptin replacement in ob/ob mice, the Scd1 gene expression is extremely downregulated (∼20-fold in SQ and ∼100-fold in ICV) as compared to their respective controls.
Another gene for degradation of dhurrin, the p- S -hydroxymandelonitrile lyase gene (Sb04g036350) was extremely downregulated (0.20 fold; Figure 5B; Additional File 1: Table S1).
It is well-known that multiple myeloma (MM) cells have a high expression level of the miR-17-92a miR-17-92a miR-17-92ama miR-92a levels in aclustermphoid leukemia or non-Hodgkin's lymphoma are extremely dowhereasated.
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35 Consistent with its putative role as a tumour suppressor, the expression of cadherin-10 is downregulated in prostate cancer in which its expression is extremely low or undetectable.
Recently, it was shown that BARD1 is downregulated in a proteasome-dependent manner following treatment with an extremely cytotoxic dose of UV (70 J/m2 ) that induces substantial levels of apoptosis [26].
However, 4 pathways were downregulated on 5th DOL and 5 pathways were downregulated on 28th DOL in the group of extremely preterm infants.
Chromobox 6 (CBX6) is downregulated in breast cancer.
These pathways were all downregulated (Figure 2).
Green: upregulated genes; red: downregulated genes.
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