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4 Although a recent study succeeded in minimizing the environmental factors, 5 another confound remains extremely difficult to tackle: reverse causality.
It was made clear from the outset that some issues were either beyond the scope of the project or would be extremely difficult to tackle e.g. providing services for children.
Whether in vivo receptor interactions occur at systems level across neural circuits, within neurons via signaling pathways, or at molecular level by direct receptor receptor contact, however, is highly debated, and is extremely difficult to tackle with existing tools.
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Experiments with wine are extremely difficult to undertake.
This question is very difficult to tackle in primary keratinocytes, as their MT density is extremely high.
"It wasn't hard, it was extremely difficult to take.
It was simply too difficult to tackle before elections.
This problem is difficult to tackle for large.
Unfortunately, the very complexity that makes the inner ear such an exquisite structure has also made it an extremely difficult organ to tackle for researchers.
Quantum computers are extremely difficult to program and highly unpredictable — a problem that will take quite some time to tackle.
That portion of the show was extremely difficult to watch — it felt like a violation far beyond anything the show has tackled before.
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CEO of Professional Science Editing for Scientists @ prosciediting.com