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This is extremely challenging to do using conventional technologies.
This is extremely challenging to do with wild strains, many of which are flocculent and thus impossible to count accurately.
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Give Me Your Love is extremely challenging to perform.
Basic everyday matters, such as getting a mortgage, can prove extremely challenging to a person if their primary identity document doesn't match how they appear.
H. cinaedi is extremely challenging to isolate, and therefore needs special laboratory practice.
Our findings do suggest that, at present, tackling childhood obesity within primary care is extremely challenging to the point that an almost fatalistic perception that "nothing works" has developed.
"It is extremely challenging to get to the Olympic Park venues by bike.
Nevertheless, she says, personalized learning is "extremely challenging to implement well".
Immune-mediated ADRs are rarely observed during clinical trials and are extremely challenging to forecast.
First, personalised autologous cell therapy is extremely challenging to develop for widespread clinical use.
"We are challenging them to do that".
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