Sentence examples for extreme trials from inspiring English sources

He brazenly courted scandal, revelled in most of it, asserted that "hot sex sells clothes," and certainly subjected his models — like the mannequins in the catalogue — to extreme trials.

This also ensures that the following analyses are sufficiently conservative, and not due to these few extreme trials.

Freidlin and Korn [ 26] suggest that the most appropriate comparator for the x % of trials stopped at the first interim analysis is the average treatment effect estimate of the same outcome in the corresponding x % most extreme trials in the fixed sample-size design (the design that has no interim analyses).

Similar notions of extreme trial-and-error date back to the ancient Greeks, including Lucretius and Empedocles (Gliboff 2000).

However, at times of extreme trial and challenge, when vision, courage and leadership is called for, they are limited and are less likely to pioneer the tough, unpopular choices and initiatives that the moment may call for.

The methods and results for the phase III EXTREME trial have previously been described [ 2].

The baseline demographics of the QoL population were broadly similar to those in the ITT population of the EXTREME trial.

Data from the PFE-alone group of this study were consistent with the published data from the EXTREME trial, which compared PFE with platinum/5-FU alone [ 1].

In this study, we conducted a retrospective analysis of the EXTREME trial to investigate outcome according to tumor HPV and p16 status.

A total of 442 patients were randomly assigned to receive treatment in the EXTREME trial, 220 to platinum fluorouracil and 222 to platinum fluorouracil plus cetuximab.

In conclusion, this analysis of the EXTREME trial indicated that the survival benefits of chemotherapy plus cetuximab over chemotherapy alone were independent of tumor p16, HPV or combined p16/HPV status.