Multiple alignment of all predicted examples revealed length heterogeneity ranging from 34 to 78 residues, with extreme sequence diversity upstream of a carboxyl-terminal 23-amino acid region of extremely strong sequence conservation, suggesting that the extended, unalignable N-terminal regions largely reflect incorrect start site predictions.
The extreme sequence divergence of CRISPR-specific endoRNases and their RNA substrates has obscured homology-based comparison of RNA recognition and cleavage mechanisms.
For the latter case, however, it is really necessary to validate the correlation between the existence of know alleles and the polymorphic pattern of markers, particularly for gene linked SSR markers, due to the extreme sequence similarity among different functional and nonfunctional alleles at the Pi2/9 locus (Su et al. 2015; Zhou et al. 2007).
This satellite is characterized by preservation and extreme sequence conservation among evolutionarily distant insect species.
It is thought that the extreme sequence homogeneity among monomers is maintained by concerted evolution or it may be linked to the replication mechanism of this atypical mitochondrial genome [7].
The extreme sequence conservation of HCEs suggests that these elements play vital roles for their host; however, deletion of HCEs failed to reveal any critical abnormalities and showed an apparent lack of association to nearby genes [32].
This group of organisms possesses extreme sequence homogeneity in their marker genes and also shares almost similar biochemical properties thereby making it exigent to differentiate them by biochemical characteristics.
Since such an extreme sequence conservation at species level is well documented in the case of Mycobacterium, further analysis of MIP would be sagacious to have an explicit understanding of taxonomic identity and specific physiological attributes of this bacterium, particularly in the context of evolution and speciation.
The overall genome difference between T. p. pallidum and T. p. pertenue strains by this measure was only 0.36% to 0.37%, indicating an extreme sequence similarity between T. p. pallidum and T. p. pertenue despite the fact that strains belonging to both subspecies cause distinct and quite different human diseases.
Despite extreme sequence dissimilarity among individual members, informatics studies revealed previously cryptic homology in the cyclodehydratases.
In cases of extreme sequence divergence, Phyre [ 39] was used to evaluate potential secondary structure.
