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It is more likely to have an extreme proportion of positive results when the total number of studies related to the gene is small (an extreme example: only one study conducted for a gene and results showing positive association, resulting in a proportion of positive results equaling 1).
Finally, step 4 removes unreliable wells that either have an extreme proportion of expression or extreme cell gene expression values.
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The satirical magazine, which has been the subject of controversy in the past, was the victim of a terrorist attack of extreme proportions and somehow, especially for Europeans, this attack hit particularly close to home.
Oxfam, which provides water, cash grants and sanitation facilities, said in January that a "humanitarian crisis of extreme proportions" could unfold if instability continued, warning that unless the crisis was addressed it would be almost impossible to stop it becoming deadly.
But it's grown to the kind of extreme proportions that in earlier eras have outraged Americans into enacting reforms.
But the military offensive has lead to a refugee crisis of extreme proportions: as many as three million people have been displaced, their homes and villages destroyed.
There were all kinds of people at the event – old people; young people; cybergoths; a man in flares of extreme proportions; a really drunk woman screaming "sippy cup"; a guy in a onesie.
a For categorical variables, Fisher's exact test was used for extreme proportions (expected count <5) instead of Pearson's chi-square test.
Jean Paul Gaultier created some of the most extreme proportions, mixing grown-up styles with childish shapes, including ruffled knits (at Kirna Zabête in SoHo).
Despite comparable levels of total recombination (49.3% and 52.8%, respectively, for the assayed portion of chromosome V), we found an extreme difference in proportion of double-crossover events with double-crossover products not detected in oocyte meiosis while accounting for 3.4% of total crossover products from male spermatocyte meiosis.
Between these extremes, the relative proportion of specimen- vs observation-based occurrences in the 24 classes formed a continuum, with a few classes having an almost equivalent number of occurrences of both origins (e.g. Insecta).
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com