Exact(4)
Mutmap-like strategy and extreme linkage analysis were then applied to fine map this locus within 1.14 cM.
This approach works well in North America and Europe, where the 3 major lineages predominate because of extreme linkage disequilibrium (7 ).
We feel that this shortcoming is by no means the same scale as the existing polygenic populations that are segregating for thousands of genes some in extreme linkage (Kroymann and Mitchell-Olds, 2005, Nature 435, 95-98).
The results of the two methods both suggested that the major locus controlling weeping trait was located on mei pseudo-chromosome 7. To confirm this conclusion, an extreme linkage analysis was conducted considering weeping trait as a complete recessive monogenetic trait.
Similar(56)
For a pair of random gene expression profiles, we computed two most extreme LA linkage scores (across all the 667 marker blocks), one for the positive value and another for the negative value.
First, Szilágyi and colleagues consider only the two extremes of linkage (all or none), which leaves open the question if more specialized enzymes could have been maintained by limited linkage.
By 1996, experts like Prof. Jeremy B. Rutter, head of classics at Dartmouth, judged the chronological gap too extreme for any linkage.
The opposite extreme is perfect linkage.
Moreover, some inversions have closely linked breakpoints producing extreme cases of linkage disequilibrium; thus, we repeated the analysis by grouping inversions in four 'inversion systems': 2R j/+, 2R b/ bc/+, 2R d/ u/+ and 2L a/+.
Because estimates from the full data set and from the clock-like data set were the same, the neutrality requirement has not been severely violated, although the assumption of free recombination might not be strictly valid when comparing the genomes of B. arachnoides (2n = 62) and C. lugens (2n = 16) because they represent the most extreme difference of linkage groups within NP.
The overall physical coverage was 155.4 Mbp compared to the 207.3 Mbp of T1E (75.0%) and the 211.9 Mbp of T×E (73.3%), and there was low coverage between mapped markers at the extremes of certain linkage groups (compared to T1E): coverage of G4, G5, and G8 was only 32.4%, 36.4%, and 70.2%, respectively of the distance of the same groups in T1E.
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