It may be argued that neurons upon exposure to conditions detrimental to their survival try to compensate by altering sizes; however, in case of extreme insults, the compensatory mechanism(s) fail and the neurons undergo degeneration.
The effect advances from the threshold of perception, through intermediate steps, to an extreme thermal insult, grand mal seizures, and finally death.
Later, Mr. Montebourg released a letter to Mr. Taylor, calling the executive's comments "extreme" and "insulting," adding that they pointed to a "perfect ignorance" about France and its strengths, which continue to attract international investors.
When applied ex vivo, the D. radiodurans ultrafiltrate protected Escherichia coli cells and human Jurkat T cells from extreme cellular insults caused by ionizing radiation.
At the time we went to press, about 20,000 people had signed Shafiq's petition to Nick Clegg, saying that the tweet had caused an "extreme amount of insult, hurt and anguish".
The sporadic nature of ALI and the requirement for an extreme environmental predisposing insult (such as sepsis or trauma) make traditional family linkage studies of ALI unreasonable.
For a city that has been hit hard by the global collapse in oil prices, this is extreme injury added to insult.
He went to the extreme of unleashing viscous insults at the parents of a fallen Muslim American soldier who died in service to his country.
In a campaign season so far defined by extraordinary insults and extreme rhetoric, the 2016 Republican presidential nomination fight could ultimately be decided by lawmakers, party activists and lawyers.
Nonetheless, cells exposed to extreme physicochemical or mechanical insults die while releasing elevated amounts of damage-associated molecular patterns (DAMPs), that is, endogenous molecules with immunomodulatory (and sometimes cytotoxic) activity.
