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A more extreme instance of a polis that was never fully synoecized in the physical sense was Sparta, which, as Thucydides elsewhere says, remained "settled by villages in the old Greek way".
The nature of the microchromosomes in birds, with their high recombination rates, high amount of GC-rich sequences, GC content and gene densities appears to be an extreme instance of a general trend.
Despite the unusual and often severe nature of symptoms, FMSS can be seen as an extreme instance of a common phenomenon in predictive coding networks the overweighting of prior beliefs over sensory data which underlies normal experiences from optical illusions to placebo effects.
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(The most extreme instance of such an approach is undoubtedly the hold-up in L'Argent, which we don't see at all - it's thanks to the soundtrack alone that we know what's going on).
But the case of handicaps is just an extreme instance of what is always present, namely each individual has a set of traits and natural powers bestowed by genetic inheritance and early socialization, and these differ greatly across persons and greatly affect people's access to valuable ways to live.
That it might also be a transfer of wealth from future taxpayers to incompetent or opportunistic financiers — an extreme instance of privatizing gains and socializing losses — did not trouble the equity markets, which generally don't fret much over fairness.
Genes active in one inbred line but inactive in another represent an extreme instance of allelic diversity defined as single-parent expression [4].
A recent bombshell Rolling Stone article about an alleged gang-rape at the University of Virginia seemed to show an extreme instance of sexual violence on campus.
Iago is an extreme instance of the kind: that is to say, of diseased intellectual activity, with the most perfect indifference to moral good or evil, or rather with a decided preference of the latter, because it falls more readily in with this favourite propensity, gives greater zest to his thoughts and scope to his actions".
This approach may be more appropriate when the association between Y and X is not driven by the longitudinal trend of X or an average level but rather an acute or extreme instance of exposure.
Over the past two centuries this has most often happened during the most extreme instance of national purpose: mass warfare.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com