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A similar idea about the regulation of KATP channel numbers has been put forward by Flagg et al. [23] and this could explain why a moderate, but not extreme, increase in SUR2A levels results in increased number of sarcolemmal KATP channels.
"The facts are quite startling when you look at the extreme increase in the number applied," he says.
Large Eddy Simulation (LES) alleviates the serious area of turbulence modeling uncertainty but with an extreme increase in computational cost.
Densification due to the extreme increase in the population of urban and rural regions following rapid economic growth has occurred in many areas of the world.
The rapid development in information and computer technology has facilitated an extreme increase in the collection and storage of digital data.
Over the last decade, an extreme increase in the application of fiber reinforced polymers (FRPs) for strengthening of reinforced concrete (RC) structures has been observed.
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He said that extreme increases in oil prices accompanied by declines in stocks have been rare over the last 35 years.
The second scenario, which assumes extreme increases in dichloromethane in the coming decades, indicates that the hole would still be recovering into the next century.
The most extreme increases in occurrence in response to higher GC3 are those of CTG, GCC, and GTG, and the largest decreases are those of AAA and GAA.
The chills phenomenon is of interest because when they are experienced, there are extreme increases in autonomic nervous system arousal that are much more significant that those relating to "high pleasure".
These changes may reflect cellular metabolic rewiring necessary to enable extreme increases in secondary metabolism.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com