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An extreme high value of ruggedness number occurs when both variables are large and slope is steep (Umrikar 2016).
A random effects model was used to incorporate unexplained heterogeneity and resulted in a global incidence estimate of 0.31 [0.19; 0.50] symptomatic RV infections per personyear of observation for children below 2 years of age, and of 0.24 [0.17; 0.34] when excluding the extreme high value of 0.84 reported for Mayan Indians in Guatemala.
The efficiency remained significant even after removing an extreme high value (M*= 1.39, p= 0.008).
The result was consistent, with a mean value of 17.41, and most of the REHH values were within the 5% extreme high value.
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In 1999, a major producer of both glyphosate and GM crops declared that glyphosate residue levels of 5.6 mg/kg in glyphosate-tolerant soybean were considered to be extreme high values [30].
Those with extreme high values of vitamin D may have been included in the "normal" group.
Possibly, in patients with such extreme high values, a longer discontinuation is needed.
One patient was excluded due to extreme high values for NT-proSST (71,300 pmol/L).
In the illegal pathway module, the parameter values tended to be clustered at lower values with a few extreme high values.
We therefore think that the results could improve if we had sorted samples based on extreme high values of radiographic damage score versus patients with hardly any damage.
Also, some extreme high values in PM10 data set can also bias the estimations at the process of normal score transform.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com