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There was a paucity of larger studies with extreme estimates of VAI rate.
Compared to the univariate analysis, the multivariate models produced noticeably less extreme estimates of intervention effects.
Amongst the ten high quality studies and excluding two small-scale outliers in each extreme, estimates of a home preference ranged 31%to87%7%.
This is most evident for extreme estimates of allelic imbalance, which appear as horizontal lines of dots at the top and bottom of Figure 2.
Simulations with N = 3000 had no extreme estimates of Ne, whereas simulations with N = 10,000 had a small number of outlier estimates that were greater than 40,000 or less than minus 20,000.
Extremes in food consumption or toxicant occurrence may lead to extreme estimates of exposure in some individuals, but may not be reflective of the true (usual) exposure over a longer time frame.
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However, given the wide dispersion of values for most estimates, at a minimum sensitivity analyses should be conducted to explore the impact of more extreme estimates on the model output.
Refusing such a bargain also requires an extreme estimate of how much American public opinion will swing in the conservatives' direction.
An extreme estimate of the size of the fractional change can be made when νmax = 1 and νmin = 0.
The National Treasury Management Agency, the government body in charge of Ireland's assets and liabilities, responded to the downgrade by saying that S&P had used an "extreme estimate" to calculate the size of the bank bailout.
The funnel plot revealed an excess of smaller studies with extreme estimates, both high and low, of VAI rate.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com