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These materials with extreme disorder could resist damage because disorder, stabilized by entropy, is the equilibrium thermodynamic state.
Since invariant and semi-invariant phase relationships of direct methods are derived using the assumption that the electron density is atomic, extreme disorder of solvent may lead to difficulties at the structure solution stage.
There is no clear criterion for extreme disorder.
In contrast, only 49% of hSP and 42% of hNNuSP met our criterion for extreme disorder.
Of the 51 autoantigens in our hNuSysAAG database, 76% of the proteins met our criterion for extreme disorder, which was comparable with 75% of the proteins in hNuSP.
An even more dramatic demonstration of the correspondence of regions of extreme disorder and a lack of potential T cell epitopes will be discussed in Fig. 5. Taken together, these data suggest that disordered regions, probably because of their conformational flexibility, masking by nucleic acids and other proteins and their proteolytic lability, make poor antigens.
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In patients with erythromelalgia, Nav1.7 is activated at lower potentials, whereas in patients with paramyxal extreme pain disorder, Nav1.7 channel activation is extremely prolonged.
Paroxysmal extreme pain disorder (PEPD) was first described in 1959 as a familial disorder characterized by very brief episodes of excruciating rectal pain associated with flushing of the buttocks and legs, ocular pain and flushing of the eyelid and periorbital skin, and submaxillary pain [1].
Families of Brady's victims welcomed the decision to keep him at Ashworth hospital on Merseyside, where he will continue to be treated for an extreme personality disorder and schizophrenia.
In "The Statesman" and elsewhere, Plato makes clear that tyranny — a state of extreme political disorder in which a ruler has absolute power and uses it to only selfish ends, with disregard for law, wisdom, or the welfare of the populace — is the opposite of the virtuous kingship of the ideal state.
Paroxysmal extreme pain disorder.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com