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One locus had extreme deficiencies and was removed from all analyses.
This comment underscores the extreme deficiencies in understanding the process of adaptive radiation.
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26.4% of females and 18.4% of males have extreme deficiency of 25(OH D.
28.4% of UAE nationals and 17.5% of visitors of other nationalities have extreme deficiency of 25(OH D.
People with albinism, also known as albinos, have an extreme deficiency of melanin pigmentation that makes their skin and hair very pale.
In addition, this reflects an extreme deficiency state rarely encountered in the human population in modern times.
The concept that extreme deficiency or excess of an agent can have the same clinical effect is not without precedence.
Altogether these data in vivo are consistent with the extreme deficiency of circulating FVII caused by the IVS6 + 1G > T change.
The latter point is illustrated by the extreme deficiency of chains of DP12 to DP25 in the Atss2, Atss3 double mutant.
In this way, our study differed fundamentally from previous studies that used either wild-type mice, able to synthesize their own ascorbate 22, 23, or that used Gulo−/− mice under conditions of extreme deficiency 30– 30.
Extreme deficiency in DP12 to DP28 chains occurred in the double mutant, far more severe than the summed changes in SSII- or SSIII-deficient plants lacking only one of the two enzymes.
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