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Within the more extreme context of highly malignant tumors, HSF1 drives a unique transcriptional program that is distinct from heat shock and includes genes supporting oncogenic progression, cell-cycle regulation, and metabolism.
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There is no authoritative evidence the technique can work in such extreme contexts, but studies have shown it can prevent relapses of depression and anxiety in the wider population.
The Special Forces context provides a particularly interesting illustration of how to build Project Capabilities over time, to the extent that they have been carrying out successfully multiple projects in extreme contexts for more than 60 years.
Particularly, how performance is maintained in the rich varieties of 'normal' and more extreme contexts in which people try to adhere, and to include the effects of their illness, type of treatment, emotional stress, cognitive impairments, and patients' social and financial situations.
Ten-to-one would sound insulting in a less extreme political context.
Unfortunately, we did not measure cardiac output due to the extreme emergency context.
For instance, there is no evidentiary basis for the fear that the decriminalization of assisted dying would relax the inhibitions that medical professionals presently feel for resorting to assisted dying in all but the most extreme of contexts.
If there is a personal reason or regional context (extreme weather) which would make a deadline a hardship, we would certainly consider giving some reasonable flexibility to the date.
In the Israeli-Palestinian context, extreme elements on both sides easily dominate supposedly centrist governments that are either unwilling or unable to make peace.
Tempos were sometimes extreme but, in context, always seemed right: detail was not lost in fast movements, and shape and momentum were sustained even in the most extraordinarily slow ones.
There is, however, a more moderate form of postmodernism worth keeping, which emphasizes the extreme complexity and context sensitivity of cultural systems and questions whether assertions of truth in any particular culture, including scientific culture, are in fact part of the culture's ideology.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com