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'extreme changes' is an acceptable phrase in written English.
You can use it to refer to a major or sudden alteration in something. For example, "The government made extreme changes to the tax code last year."
Exact(60)
(Unlike the other planets, Uranus spins on its side, making for extreme changes in viewing angles).
Trying to make extreme changes in the food we eat conflicts with those communal eating pleasures.
The Huang He is subject to extreme changes in summer and winter flow.
These extreme changes of body temperature were thought to have a beneficial effect on circulatory function.
He said he didn't anticipate any extreme changes after the season.
The teen years are often tumultuous, with adolescents experiencing extreme changes that affect their brains as well as their bodies.
Moreover, the sensor activity in vitro was stable with extreme changes in pH.
Here, geovisualisation is used to depict the extreme changes in the landscape.
Friends and family began to notice extreme changes in Karen's eating habits, despite her attempts at subtlety.
Extreme changes in moisture, fertility, elevation, and acidity within a single field can make management decisions challenging for producers.
Pollution and extreme changes in water quality and levels have been significant factors in this alarming decrease.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com