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Unlike the case described by Wik et al. (2010) where a patient with a femoral condyle endoprosthesis experienced a fracture as a result of extreme bone resorption, the patients in our study with an osseointegrated prosthesis were not subjected to such significant stress shielding as a result of the implant.
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Anti-resorptive agents all inhibit bone resorption.
These implants can be used for revision of loosened femoral stems with extensive bone resorption of the proximal femur, enlargement of the medullary cavity, or extreme thinning of the cortical bone in the proximal region of the femur.
Upon arriving in bone, breast cancer cells disrupt normal bone remodeling by increasing bone resorption, leading to several serious clinical complications including life-threatening hypercalcemia, spinal cord compression, fractures, and extreme bone pain, which result in a significantly decreased quality of life [ 1, 2].
Kajiya, H. Calcium signaling in osteoclast differentiation and bone resorption.
In the 30's, bone resorption begins to outpace bone formation, causing a gradual loss of bone density.
A third option is salmon calcitonin, a hormone that inhibits bone resorption.
Birkhold, A. I. et al. The influence of age on adaptive bone formation and bone resorption.
Bisphosphonate Withdrawal: Effects on Bone Formation and Bone Resorption in Maturing Male Mice.
Estrogen and testosterone are believed to block bone resorption, so as women reach menopause and their estrogen level drops, resorption speeds up, leading to rapid bone loss for the next five to seven years.
Reduced marginal bone resorption was also shown.
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