On the other extreme, an assembly consisting of many short contigs covering only the inter-repeat regions of the genome could have very high accuracy although contigs might be too short to be used, for example, for gene-annotation efforts.
Reliability aspects are of extreme importance for assembly and packaging, which has become a limiting factor for both cost and performance of electronic systems.
For example, in the extreme case, an assembly consisting of one large contig of roughly the size of the genome is useless if mis-assembled.
This extreme conservation complicates assembly of full-length sequences from genomic DNA, and has undoubtedly slowed recognition of this new structural motif.
As observed in Zhang et al. (2012) this extreme heterozygosity makes assembly significantly challenging.
In an extreme case, an assembly with the highest N50/NG50 length and largest total size could comprise of, one extremely long scaffold and thousands of very short scaffolds.
By focusing on low-coverage long reads and short reads with high coverage, we wished to stress-test all assemblers against the most extreme instances of the sequence assembly problem, especially, where assembly quality is of essence.
As a means of basic structure assembly in extreme conditions, they could very well come in handy, but more complex designs might be beyond them.
This rechargeable battery assembly showed extreme stretchability up to 300%, with a capacity of 1 mAh/cm.
