With McGregor, of course, even more extrapolation is required, and his nonexistent record adds a bit of suspense to next weekend's fight: we don't know exactly what he will look like in a boxing ring.
While no extrapolation is required to estimate outcomes for No-ART patients, uncertainty relating to extrapolation is an important problem in the evaluation of ART.
Therefore, an extrapolation of the observational values was required.
For instance, Mayweather fought at welterweight (a hundred and forty-seven pounds) only a dozen times, which meant that figuring out how good he really was required a great deal of extrapolation.
For risk assessment using acute-to-chronic extrapolation, the inclusion of a protective extrapolation factor is required and analysis of existing acute and chronic effect values is a prerequisite for the derivation of an adequate assessment factor.
Thus, additional time extrapolation might not be required if OELs are derived from human sensory NOAECs.
As noted above, in vitro to in vivo extrapolation methods will be required to translate in vitro test results to in vivo situations using an appropriate internal tissue dose metric (Rotroff et al. 2010; Yoon et al. 2012).
Chiu et al. suggests in more detail that if UERSNCD < TEL, the POD corresponding to that TEL can be derived directly, whereas the case UERSNCD > TEL indicates that low-dose extrapolation from the SNCD is required to reach the dose associated with the TEL (where UERSNCD/TEL measures the extent of extrapolation).
In general, calibration for every lineage will be required, as extrapolation of rate constants where the lineage is calibrated to other lineages will not, in general, be justifiable.
