Sentence examples for extrapolation to humans from inspiring English sources
The importance and relevance of these findings may be used for dose selection in chronic studies, and extrapolation to humans for risk assessment and management.
According to the present data, based on an animal model and extrapolation to humans, the expected radiation exposure in a human study is acceptable.
Interpretation of the results, adjustments to them, and extrapolation to humans may therefore be more accurate than for other animal models that are less often used in laboratories.
Dose extrapolation to humans was based on linear scaling of injected activity per gram tissue between animals and humans and computed using OLINDA software.
Primates were used in this preclinical investigation as their metabolism and physiology are closer to those of humans than those of rodents, and hence, extrapolation to humans is more reasonable.
On the basis of dosimetric extrapolation to humans first therapeutic applications in patients should start with 4 repeated administrations of 3-5 GBq to limit the cumulative kidney dose to <27Gy.
However, the measurements are indirect, based on animal models, and require extrapolation to human exposure conditions.
Mouse biokinetic small animal PET/MR based data and extrapolation to human circumstances in %ID per organ (mean %ID).
The results from in vitro studies in cell lines present a huge challenge in their evaluation and extrapolation to human cancers absent the data to make such a leap.
In addition, TACs that were calculated based only on animal organs (i.e., no extrapolation to human values) were used to calculate additional dose estimates to provide an estimation window for the human dosimetry (referred to as 'NE' for no extrapolation).
