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Extrapolation can be risky.
Given its single-center retrospective nature, results obtained herein will need to be confirmed in a larger prospective multicenter cohort before any extrapolation can be made.
The first reference point to serve as input for the linear extrapolation can be determined using the Gini coefficient (G) prior to BPS as well as the corresponding quality (Q) and time (T) values.
Alternatively, when there is a missing quantity at starting or stopping dates, extrapolation can be used.
As in the case of ordinary and stochastic differential equations, extrapolation can be repeated to obtain even higher-order approximations.
Information on comparability trial data and extrapolation can be found in a biosimilar medicine's European Public Assessment Report.
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But such extrapolations can be dangerous.
"Such extrapolations can be hazardous," Harold M. Schmeck Jr. wrote in The New York Times in a review of "The Doctors" in 1967.
Probably, some extrapolations can be made to uterine adenosarcoma.
There are also few indications of a settled forest policy on which future extrapolations can be based.
As models are mechanistic, extrapolations can be conducted by modifying system-specific parameters toward the organism or age group of interest while maintaining an understanding that drug-specific parameters remain constant.
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