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These 3D tissue-like model systems can reduce the uncertainty involved in extrapolating risk between in vitro cellular and in vivo models.
Extrapolating risk score errors in MA plans is consistent with the methodology used in the Medicare fee-for-service program and enables Medicare to recover risk adjustment overpayments.
Our recruitment methods (recruiting volunteer subjects who lived in areas where human/NHP contact was the greatest) prevent us from measuring, comparing and extrapolating risk of bite injury and SFV infection to the general population of the areas sampled in Bangladesh.
As Noble and colleagues pointed out, caution is needed when extrapolating risk models to a different population [ 20].
In addition, the choice of weather data may limit the potential for comparisons of risk maps for different areas and for extrapolating risk maps to future scenarios where weather conditions are unknown.
Issues in extrapolating risk estimates based on time-series studies in one population to estimate the amount of life lost in another population are also discussed.
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Limited research resources should focus on biologically plausible, detectable risks, recognizing that protecting the general population which has very low exposure involves extrapolating risks downward from higher exposure studies, and accepting that we may never prove whether risk estimates at very low exposures are real or not.
Our findings do not support using a fixed multiplier to calculate total CVD risk based on CVD mortality risk, and caution is warranted when extrapolating the risk of CVD mortality to the risk of total CVD.
26 29 Caution is needed when extrapolating a risk model or score developed in one population or setting to a different one for example, secondary to primary care, adults to children, or one ethnic group to another.
Conceptual model 2 in Science & Decisions NRCC 2008) employs HVDs to estimate the dose response from exposure to a toxin (HVD modeling) and uses this dose response to extrapolate risk to low doses.
Currently, an etiologic mechanism for associations between low-level radiation and circulatory disease risk is unclear, so there are no sound biological grounds on which to base selection of a model for extrapolating the risks to low doses or low dose rates (AGIR 2010).
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