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The judgments are based on a few animal tests extrapolated to humans, with all sorts of jumps and gaps.
Toxicity screening based on animal liver cells cannot be directly extrapolated to humans due to species differences.
However, the data obtained from such methods cannot be directly extrapolated to humans and often do not provide a safe starting dose for first-in-human studies.
These studies show the rat is a very poor model for humans and toxicity in the rat cannot be extrapolated to humans.
The model was extrapolated to humans and the human model adequately simulated measured plasma OTC concentrations after intravenous (7.14 mg/kg) and oral exposures (6.67 mg/kg).
Just because scientists can create myriad "models" of human disease, all differing by one or two pieces of genetic material, does not mean that the results can safely be extrapolated to humans.
If these data from animals can be extrapolated to humans, we speculate that the importance of pulmonary venoconstriction in exacerbating pulmonary edema may vary over time in patients with acute respiratory failure.
Further researches are necessary to see if our findings can be extrapolated to humans.
Still, Mousseau cautions that the results should not be directly extrapolated to humans.
The animal %ID/g tissue data was extrapolated to humans using the percentage kilogram per gram method [28].
The alarmist claims are based on high-dose, long-term rodent experiments that cannot be extrapolated to humans simply.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com