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As 2 Mb represents ∼1/1500 of the genome we extrapolated estimates for the number of independent variants for the circulating biomarkers (all and split by minor allele frequency bin) multiplying by 1500.
Firstly, due to the absence of patient level empirical comparative study covering a time span consistent with the assumed survival horizon for MBC patients, the Markov model extrapolated estimates for 5-year OS and PFS, as well as costs for both nab-paclitaxel and conventional paclitaxel from the results of a pivotal comparative trial.
Put simply, it is now possible to compare the 2015 survey estimates to the 2014 extrapolated estimates.
In many meta-analyses the extrapolated estimates will not violate the constraints.
Extrapolated estimates suggest that 15.9 million (range 11.0 21.1 million) people might inject drugs worldwide [ 1].
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If an extrapolated estimate violates a constraint, it could be a valuable indication that the model is inappropriate when applied to all the studies.
First, because the Hunter New England community is a well- defined population with a limited number of hospitals where persons with acute respiratory illness are hospitalized, HNEPH was able to implement population-based surveillance for acute respiratory illness hospitalizations and deaths, eliminating the need to extrapolate estimates from a limited sample of the population.
Because bicycle ridership is quite variable across regions, it is impossible to extrapolate estimates of the epidemiological burden.
Extrapolating estimates of true and false positive rates at this probability, about 11,000 genes, more than half the large set of genes tested, are predicted to have a highly redundant paralog.
Recently, the risk assessment and atmospheric modeling communities have recognized the importance of developing approaches to extrapolate estimates from other studies in situations where input data are limited or comprehensive models are impractical.
To some extent, O'Brien can extrapolate, estimate and envision.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com