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Preoperative CRT has been used by many oncologists especially in North America for patients with clinical T3 disease based on extrapolated benefits from postoperative CRT and a number of nonrandomised studies demonstrating significant pathological complete response (pCR) rates and acceptable acute toxicity profile with the use of preoperative CRT.
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When extrapolating benefits in experienced quality of life and glycemic control over a lifetime, the ICER point estimates from our analyses suggest that CGM is a cost-effective technology, based on the ICERs of commonly accepted diabetes therapies (21).
Direct hospital costs were obtained from a clinical patient administration database and cost-utility analysis performed from the perspective of the secondary care provider extrapolating benefits of surgery to the remaining statistical life-expectancy of the patients.
Testing of a specific supplement may not be extrapolated to benefits from any other strain of the same species, and testing results do not imply that comparable benefits will be imparted from other LAB (or other probiotics).
As another major difference between the two HTA systems, efficacy data are never extrapolated for benefit assessment in Germany if data on clinical effectiveness are limited or absent (Table 4).
There is no evidence so far to guide us to extrapolate these benefits to African populations.
Caution is required in extrapolating the benefits of surgery to diabetic patients who have lower BMI.
However, if a new test detects cases earlier in the disease process, there may not be sufficient existing evidence that can be used to extrapolate patient benefits.
However it is not unreasonable to extrapolate the benefits of a calm environment, without necessarily a transfer to a dying room, to this group.
However, it is not possible to extrapolate these benefits to the setting of cognitive dysfunction that accompanies severe sepsis with multiple organ failure.
4 Several studies have attempted to extrapolate the benefits and costs of screening to a lifetime perspective using decision analytical models.
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CEO of Professional Science Editing for Scientists @ prosciediting.com