Such data can then be extrapolated to understanding targeted therapy response and potential development of novel treatment agents, with a view to modifying or personalizing therapy.
8 In these models, liver tumors also developed in non-cirrhotic livers; thus, the results that were obtained need to be interpreted cautiously when they are extrapolated for understanding the pathogenesis of human HCC that develops in fibrotic or cirrhotic backgrounds.
However, the specific types of change (i.e., local, regional, or global), the direction of change in a particular location (i.e., positive or negative), and the magnitude of change in air quality that may be attributable to climate change are a matter of speculation, based on extrapolating present understanding to future scenarios.
Further ex vivo studies conducted to assess the biomarker distributions on NSCLC tissues assisted in our understanding of how to extrapolate these data to other NSCLC populations.
Second, how can results from experiments conducted in these simplified systems be systematically and quantitatively extrapolated to improve our understanding of nature?
Some adverse effects of these medications are known based on vigorous clinical trials, but others can be extrapolated from an expanded understanding of the complex mechanisms of the immune system.
These studies demonstrate that the pharmacokinetics of nanoparticles are more complicated than previously thought, and are often difficult to extrapolate from one evidence, thus necessitating molecular level understanding of the detailed mechanism14.
A bit later we are led to extrapolate straight and curved lines as an aid to understanding the coincidence of opposites and to moving human thought towards the God who is unknowable by reason.
Then a posttest was administered followed by two transfer/transcendence (TR) sessions aimed at understanding the extent to which the students could extrapolate their newly acquired knowledge to novel contexts.
Understanding dosimetry is essential when attempting to mimic or extrapolate human smoking behavior and in vivo doses to in vitro models.
The objective at this stage is to further improve the understanding of the drug properties in vivo and to extrapolate findings, identifying correlations or making predictions about a drug's performance in humans (i.e. clinical response).
