Unfortunately, the majority of therapeutic trials involving antiretroviral therapy, as well as antimicrobial chemoprophylaxis for AIDS-related opportunistic complications, have advanced age and/or concurrent end-organ disorders among main exclusion criteria, or the design of these studies does not allow to extrapolate data regarding older patients, compared with younger ones.
In a recent investigation into the Clinton Correctional Facility in Dannemora, New York —where two convicted murderers escaped earlier this year — the Times reported that inmates were beaten and choked with plastic bags by corrections officers in an effort to extrapolate information regarding the escapees.
Near-infrared spectroscopy (NIRS) with a vascular occlusion test (VOT) can be used to extrapolate information regarding the tissue oxygen extraction rate.
Care must be exercised also, when extrapolating conclusions regarding the effect of biological agents in the behaviour of anti-GP2 antibodies as the Belgian investigators did not find a profound effect of infliximab and adalimumab in patients followed up for 6 44 months [ 19, 21].
We cannot directly extrapolate these results regarding coronary artery bypass to other types of procedures.
In the absence of specific guidelines, current management of post-injection endophthalmitis is typically extrapolated from data regarding endophthalmitis occurring after cataract surgery despite potential differences in pathogenic organisms and clinical course.
Herein, we briefly summarise the most salient points and extrapolate with our opinions regarding any impact on a highly sensitive Tg measurement.
However there was insufficient evidence to suggest that these findings can be extrapolated to make judgments regarding employer behaviour in real hiring situations.
Current opinion regarding extrapolation of indications for biosimilar mAbs holds that if the clinical efficacy and immunogenicity testing are done in the most sensitive patient population, it would be appropriate to extrapolate to other indications of the reference antibody [ 30].
Later Tuesday, at a news conference marking the start of his fourth year in office, Mr. Netanyahu said that the fate of one house was at issue and that people should not extrapolate too much from it regarding policy on the expansion or contraction of Jewish settlements in Hebron.
Thus, the in vitro results for B cells cannot be extrapolated directly to the results regarding T cell-independent antibody production in vivo.
