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Therefore, it was often impossible to extrapolate recommendations into a western primary care setting.
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This is extrapolated from recommendations by the Centers for Disease Control and Prevention and the American Thoracic Society to test three expectorated sputa for mycobacterial culture to exclude infectious TB [ 8, 9].
Inadequate implications for clinical practice occurred mainly when authors extrapolated some recommendations for clinical practice from their results (e.g., in a retrospective study of 42 patients: "it is a suitable therapeutic option not only for initial drainage but also for salvage therapy" [ 26]).
Extrapolating the recommendation to the household domain is therefore without empirical support and is problematic as it may overestimate PA levels.
These findings have been extrapolated to treatment recommendations for patients with other causes of cerebral oedema and to newer modalities of CRRT such as CVVH or CVVHD [ 37, 38].
Often, guideline recommendations are extrapolated to diseases or patients in which the intervention was never studied (such as patients with complex multimorbidity).
These recommendations are extrapolated from solid evidence supporting the efficacy of these regimens for genital CT treatment and from clinical experience and expert consultation [ 61– 63].
The recommendations are extrapolated from adult trials, which showed that mortality is decreased in severely immunocompromised patients with CD4 <50 cells/mm with early start of ART [ 60- 62].
Some general conclusions and recommendations are finally extrapolated from this massive and intensive piece of research.
This is often forgot, when the results from these strictly selected patient populations are extrapolated into "evidence based" treatment recommendations directed towards a much larger and less selected patient population.
Patients in the medical wards, however, differ in many respects from critically ill patients, raising the question of whether these recommendations can be extrapolated to critically ill patients.
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