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Therefore, attempts to generalise or extrapolate outcomes of flux measurements from one area to another area of a given target region based on results from former flux measurements [15] are associated with high uncertainties.
This will involve both a 'within' study patient-level analysis and a model-based analysis to extrapolate outcomes into the longer term.
Considering the social and cultural differences between eastern and western countries, it is difficult to directly extrapolate outcomes obtained in the West to the people of the East.
Therefore, attempts to generalise or extrapolate outcomes of flux measurements from one area to another area of a given target region based on results from former flux measurements [ 15] are associated with high uncertainties.
We did not consider the Cox PH model, as its 'distributional free' form makes is difficult to describe the baseline hazard function (the key component required for patient level prediction) and to extrapolate outcomes beyond available observational data.
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12, 18 These findings emphasize the caution that must be taken when extrapolating outcomes of animal studies to humans.
Some caution is needed in extrapolating outcomes to patients with milder disease, but the findings are likely to be applicable to secondary care patients in general.
A long cycle length necessitating fewer cycles in the long-term phase also limited the uncertainty from extrapolating outcomes from the nalmefene clinical trials beyond the duration of the trials.
For the study by Ihle et al. [ 31] we extrapolated outcome data related to the years 2010 to 2011, as the authors used the same database as Bellomo et al. [ 21] with study populations overlapping for the years 2007 to 2009.
The use of multiple animal models and different classes/combinations of drugs in these studies makes it difficult to make direct comparisons and to extrapolate potential outcomes.
Therefore it might be dangerous to extrapolate the outcomes.
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