16, 17 Thus, we could partially extrapolate the modifying factors identified in the subgroup analyses on respiratory infections to an outcome that has a very weak relation to such infections.
Induction of miR-221 promotes increased proliferation and migration as well as decreased contractile gene expression through distinct targets, indicating that a single miRNA can extrapolate an extracellular input to mediate multiple biological outcomes [ 58].
We cannot know what will happen on 1 January, and attempting to extrapolate this future outcome from the available data is misleading.
But campaign professionals from the other parties agree with Dr Fox on one thing: extrapolating the outcome of the general election from national poll findings has become harder.
The use of multiple animal models and different classes/combinations of drugs in these studies makes it difficult to make direct comparisons and to extrapolate potential outcomes.
Therefore it might be dangerous to extrapolate the outcomes.
Most clinical guidelines extrapolate from outcomes that are determined from younger populations.
Although, different study design characteristics lead to less comparability between the two trials, the unique feature of this project is that we do not need to extrapolate study outcomes to another care settings based on numerous assumptions, as the intervention is evaluated simultaneously in both major care settings.
The main limitation of this review was the small number of studies available within the literature, which, in turn, limited, to some degree, the ability to extrapolate the outcomes of this review toward realistic public health recommendations when referring to ergocalciferol and cholecalciferol supplementation.
The prediction models can be used by future studies to extrapolate short-term outcomes to a long-term horizon or to indicate for which neonates long-term follow-up is required, as their outcomes (either absence or presence of sequelae) cannot be adequately predicted from short-term outcomes and clinical background characteristics.
This will involve both a 'within' study patient-level analysis and a model-based analysis to extrapolate outcomes into the longer term.
