We extracted trial characteristics and compared them by trial type.
Then, we extracted trial data from the time-course data.
All studies that extracted trial author-industry financial ties or employment data reported it in the review.
Two reviewers independently identified trials, extracted trial-level data and performed risk of bias assessments using the Cochrane Risk of Bias tool.
To empirically assess the risk of bias in the treatment effects in reviews, we will perform stratified analyses across trials according to all the different extracted trial characteristics and derive p values for interaction between trial characteristics and treatment effect.
Two reviewers independently identified and extracted trial-level data from randomized trials investigating unfractionated or low molecular heparin administered to patients with sepsis, severe sepsis, septic shock or DIC associated with infection.
Several researchers attempted to extract trial characteristics, namely population description, study interventions, and outcomes, from journal article abstracts.
We use a standardized protocol and reporting form to extract trial characteristics, patient data, outcomes and study quality.
From each trial data were extracted on trial design, details of honey and control interventions, outcome measures, statistical analysis, and geographic location of the trial.
