Sentence examples for extract library from inspiring English sources
In collaboration with biologists, this crude extract library has been screened for activity in cell-based and pure enzyme assays designed to identify promising marine natural product lead compounds for the development of drugs.
We identified ursolic acid, a natural pentacyclic triterpenoid that occurs widely in traditional Chinese medicinal herbs, as an inhibitor of PTP1B by screening an extract library of the traditional Chinese medicinal herbs used a diabetes clinic.
Here we describe a pilot scale high-throughput screening (HTS) campaign against the first and second committed steps in the pathway, catalyzed by DXP reductoisomerase (IspC) and MEP cytidylyltransferase (IspD), using compounds present in the commercially available LOPAC1280 library as well as in an in-house natural product extract library.
The extract library is prepared from diverse microbes isolated from variety of ecological units in India.
The metabolite extract library samples were screened for the ability to induce glucose uptake in insulin stimulated differentiated L6 myotubes.
We explored the microbial metabolite extract library in search of compounds that enhance glucose uptake in skeletal muscle cells in presence of insulin.
For bacteria chemical diversity was not determined prior to extraction, leading to redundant strains and compounds in many natural product extract libraries.
The effort to discover plant EPIs, a process ranging from identifying a hit to isolating a pure compound, presents a distinct bottleneck: the lack of comprehensive, chemically and biologically representative natural product extract libraries.
The surviving resistant clones were isolated, genomic DNA extracted, library inserts recovered by PCR and insert sequences identified by sequence analyses (Figure 3A).
Using Equation (1) and 1 Mbp sliding window (see Materials and Methods), we estimated the genome-wide copy number of MCF-7 based on the whole cell extract (WCEseq) library.
The corresponding extract and library estimates are generally in agreement.
