The cardiolipins abbreviation format is similar to the glycerophospholipids with additional specifications for extra set of sn chains: CL(1'-[sn1Chain/sn2Chain],3'-[sn1Chain/sn2Chain]).
Since our data demonstrated a role for hairy in the muscle, we next tested whether overexpression of bnl in the muscle can phenocopy the h674, h47and hACT mutant phenotype of extra TC specification.
Bennett's question was what more is needed, in terms of extra rationality specifications, to make a fictional linguistic bee from an actual honey-bee.
Considering this, we created an algorithm that finds and scores communities in a network without a subjective threshold and that does not require extra parameter specifications to find additional suboptimal subgraphs.
Simple: those extra numbers are a specification, and if there's one thing certain groups of men (it's always men) love above all other things, it's a specification on a list.
These data demonstrate that specification of extra TCs in h674 mutant embryos is dependent on normal pnt function.
Thus, the h47, h674and hACT mutant embryos which are segmented properly and yet show specification of extra TCs in the tracheal dorsal branches provide evidence that hairy's role in early patterning and in tracheal development are indeed distinct.
In contrast, overexpressing wild-type pnt in the entire trachea with btl-GAL4 led to specification of extra TCs in all tracheal branches, including the dorsal trunk (Figure 5C).
One copy of pntΔ88 in h674 homozygous embryos prevented the specification of extra TCs by h674 such that no DBs contained two TCs compared to h674 mutants alone (Figure 5E).
Therefore, we tested whether the specification of extra TCs observed in hairy mutant trachea could be due at least in part to hyper-activation of the Bnl/Btl signaling pathway.
The gain-of-function (gof) phenotypes have the opposite effect: overexpression of RasAct in the mesoderm leads to the specification of extra progenitors whereas overexpression of an activated form of N (NAct) inhibits progenitor specification [11] (see also Fig. 2D and 2E).
