Vitamin D is a group of fat-soluble vitamins that play a significant role in the regulation of bone metabolism [ 1], it also plays a major role in extra-skeletal metabolic processes, such as glucose metabolism, and in many aspects of cellular functions [ 2, 3].
In general, serpins are involved in diverse processes such as coagulation, extra cellular matrix degradation, complement activation, fibrinolysis and apoptosis [ 31].
The second method involves the formation of a metal NP layer between the ITO electrode and the poly 3,4-ethylenedioxy-thiophene:polystyrene sulfonate (PEDOT PSS) buffer layer, which typically requires an extra deposition process such as the vacuum deposition of a metal nanolayer with a sequential thermal treatment or the spin-coating of a metal NP precursor solutions [18, 19].
Hence, ridge regression must be conducted together with an extra selection process such as stepwise subset selection or truncation methods.
Up-regulated genes (more than 2-fold) were primarily related to lipid metabolism and biosynthesis whereas down-regulated genes included several processes such as transcription, cell junction, extra cellular matrix (ECM -receptor intECM -receptorothers.
Cadherins, the calcium-dependent proteins, contribute to various biological processes such as differentiation, migration and extra-cellular signal transduction of cell.
The extra fucosylations that appear on membrane glycoproteins and glycolipids are associated with several pathological processes, such as tumor metastasis, inflammation and bacterial adhesion.
The molecular mechanism of epigenetics involves many processes such as DNA methylation, posttranslational modification of histone proteins, silencing of the extra copy of the X-chromosome in females, and genomic imprinting.
This 'extra' source of variation has been suggested to play an important role in biological processes such as heterosis, fitness and adaptation to different environments, and subsequently to evolution and speciation in natural populations [ 28- 33].
