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Four extra participants were included because they had already signed up to participate in redundant timeslots on the final week of testing (i.e., we concluded data analysis at the end of the week of the 25th participant).
They were looking for extra participants – I suspect mostly to bolster the pot – and so I paid my £20 and signed up.
Completion of the study with four extra participants will allow firmer conclusions to be drawn.
These extensive recruitment efforts lead to inclusion of 271 extra participants (T4-hard-to-recruit).
To take into account a potentially higher drop out in the lower educational group, we will recruit 200 extra participants in this specific group.
However, media appearances and advertisements on local TV and radio resulted in many women being screened but did not translate into a large number of extra participants [ 14].
Similar(51)
Incremental cost-effectiveness ratios (ICERs) will be calculated in relation to the four outcome measures and will be estimates of the extra cost from adding the SMRTW intervention per extra unit of outcome/effect, e.g. the extra cost per extra participant classified as ready to return to work or per extra participant who returned to work.
However, this would have added only one extra participant as the other two non-responders at follow-up requested to be removed from the study as a whole.
The price per extra participant and price per detected and treated CIN2+ lesion was lower with a reminder letter than by self-sampling as a first reminder.
Total mean costs per participant were estimated at £8.14 per participant in the opt-in arm, and £71.93 per participant in the opt-out arm, and it was estimated that it cost an extra £209.97 per additional participant consented in the opt-out arm.
Because of the calculated drop-out rate, an extra 9 participants will be included in both the intervention and the control group, yielding a total of 108 participants for the randomized controlled trial.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com