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This extra level of control allows for a better and safer integration between an extensible system and the third-party components extending it.
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The finding that NRAGE regulates NF-κB signaling in the non-canonical BMP pathway adds an extra level of control to an already highly regulated developmental pathway.
Erdem, Jaszcuzur et al. suggest that, in living cells, this extra level of control would limit how long the DNA polymerase V spends attached to the DNA.
Therefore, the stress responsive nature of SDH Class II gene and enzyme could potentially function as an extra level of control (preventing loss of Asc to TA).
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Compared with a more direct approach, using a suicide gene such as the diphtheria toxin A chain, this prodrug-enzyme system offers extra levels of control, in terms of variation of prodrug concentration as well as prodrug bioavailability and tissue distribution.
The vertebrate organisms gain an extra level of transcriptional control by duplication of gene families.
Cloned animals have, in principle, identical genotypes and possibly also phenotypes and this offer an extra level of experimental control which could possibly make them a desirable tool for intervention studies.
The trio design with medium sequence coverage enables us to establish an accurately haplotyped Dutch reference genome, as the presence of Mendelian transmissions of variants provided an extra level of quality control and aided in the correct estimation of both genotypes and haplotypes.
It is unclear from the data presented here what the purpose of this extra level of enzymatic control is required for, however it is possible to speculate that cytoophidium assembly allows for CTPsyn activity to be rapidly up-regulated when required.
RNA Binding Proteins (RBPs) have a primary role in the post-transcriptional regulation of genes by adding an extra level of plasticity in controlling gene expression (1).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com