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I went through the normal dress fitting process, starting a little early since I knew my dress would probably need extra alterations.
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These stem/progenitor cells can acquire extra genetic/epigenetic alterations that can lead to genome instability [ 15, 69].
These results support that BRAF mutations harbour a mild oncogenic effect in comparison to KRAS and suggest that BRAF mutant colorectal cells need to accumulate extra epigenetic alterations in order to acquire full transformation and evolve to MSI CRC.
These results support that BRAF mutations harbour a mild oncogenic effect in comparison to KRAS and suggest BRAF mutant colorectal cells need to accumulate extra epigenetic alterations in order to acquire full transformation.
Also, in theory, extra-genetic alterations such as stable activation of oncogenic pathways via positive feedback loops can contribute to malignant phenotype [ 59].
The findings of Griffin and colleagues are fascinating since they show that many of the extra-articular alterations that are found in human OA can be reproduced in a small animal model of OA.
They then add the number of hours spent on an item, extra materials used, alterations, etc.
Consistent with our hypothesis, pathological changes in the basal ganglia, as well as extra-nigral structural alterations, particularly in the cortex, predict motor deficits in this model.
His wedding gowns range from $400 to $2,000; alterations are extra.
Jun was really getting into it, finding different shoes to try on with each dress and offering suggestions for alterations (an extra charge).
The YST contained a complex karyotype with several alterations, including extra copies of chromosome 12 and 14 (case 100 in Ref. 158).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com